Lee Yvonne Yin Leng, Jelinek Herbert F, McLachlan Craig S
Rural Clinical School, Samuels Building, Level 3, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052 Australia.
School of Community Health, Charles Sturt University, Albury, Australia.
Clin Hypertens. 2017 May 2;23:9. doi: 10.1186/s40885-017-0065-1. eCollection 2017.
A positive correlation between ECG derived QRS duration and heart rate variability (HRV) parameters had previously been reported in young healthy adults. We note this study used a narrow QRS duration range, and did not adjust for systolic blood pressure. Our aims are to investigate associations between systolic blood pressure (SBP), QRS duration and HRV in a rural aging population.
A retrospective cross sectional population was obtained from the CSU Diabetes Screening Research Initiative data base where 200 participants had no diabetes or pre-diabetes. SBP data were matched with ECG derived QRS duration and HRV parameters. HRV parameters were calculated from R-R intervals. Resting 12-lead electrocardiograms were obtained from each subject using a Welch Allyn PC-Based ECG system.
Pearson correlation analysis revealed no statistically significant associations between HRV parameters and QRS duration. No significant mean differences in HRV parameter subgroups across defined QRS cut-offs were found. SBP > 146 mmHg was associated with increasing QRS durations, however this association disappeared once models were adjusted for age and gender. SBP was also significantly associated with a number of HRV parameters using Pearson correlation analysis, including high frequency (HF) ( < 0.05), HFln ( < 0.02), RMSDD ( < 0.02) and non-linear parameters; ApEN ( < 0.001) were negatively correlated with increasing SBP while the low frequency to high frequency ratio (LF/HF) increased with increasing SBP ( < 0.03).
Our results do not support associations between ECG derived R-R derived HRV parameters and QRS duration in aging populations. We suggest that ventricular conduction as determined by QRS duration is independent of variations in SA-node heart rate variability.
先前有报道称，在年轻健康成年人中，心电图得出的QRS波时限与心率变异性（HRV）参数之间存在正相关。我们注意到，该研究使用的QRS波时限范围较窄，且未对收缩压进行校正。我们的目的是调查农村老年人群中收缩压（SBP）、QRS波时限和HRV之间的关联。
从科罗拉多州立大学糖尿病筛查研究倡议数据库中获取回顾性横断面人群数据，其中200名参与者无糖尿病或糖尿病前期。将SBP数据与心电图得出的QRS波时限和HRV参数进行匹配。HRV参数由R-R间期计算得出。使用Welch Allyn基于个人计算机的心电图系统，从每个受试者获取静息12导联心电图。
Pearson相关性分析显示，HRV参数与QRS波时限之间无统计学显著关联。在定义的QRS波截断值范围内，HRV参数亚组之间未发现显著的均值差异。SBP>146 mmHg与QRS波时限增加相关，但在对年龄和性别进行模型校正后，这种关联消失。使用Pearson相关性分析，SBP还与多个HRV参数显著相关，包括高频（HF）（<0.05）、HFln（<0.02）、RMSDD（<0.02）和非线性参数；ApEN（<0.001）与SBP升高呈负相关，而低频与高频比值（LF/HF）随SBP升高而增加（<0.03）。
我们 的结果不支持老年人群中心电图得出的基于R-R间期的HRV参数与QRS波时限之间存在关联。我们认为，由QRS波时限确定的心室传导独立于窦房结心率变异性的变化。
