8,9-环氧二十碳三烯酸（EET）的环氧化酶代谢产物的合成：11-羟基和15-羟基8,9-EETs。
Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.
作者信息
Barnych Bogdan, Rand Amy A, Cajka Tomas, Lee Kin Sing Stephen, Hammock Bruce D
机构信息
Departments of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, California 95616, USA.
出版信息
Org Biomol Chem. 2017 May 23;15(20):4308-4313. doi: 10.1039/c7ob00789b.
Abstract
COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.
摘要
8,9-环氧二十碳三烯酸（8,9-EET）的环氧化酶（COX）代谢产物，以前被视为强效促有丝分裂脂质介质，首次通过两种合成方法合成。这些合成材料有助于对8,9-EET的COX代谢产物进行结构确认，并进一步研究其生物学作用。
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