豚鼠脑中中枢和外周苯二氮䓬受体的区域个体发育概况。

Regional ontogenetic profile of central and peripheral benzodiazepine receptors in the guinea pig brain.

作者信息

Daval J L, Deckert J, Nakajima T, Morgan P F, Marangos P J

机构信息

Unit on Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892.

出版信息

Neurosci Lett. 1988 Sep 23;92(1):82-5. doi: 10.1016/0304-3940(88)90746-x.

DOI:10.1016/0304-3940(88)90746-x

PMID:2847091

Abstract

The ontogenetic development of 'central' and 'peripheral' benzodiazepine (BZ) receptors was investigated in 3 different regions of the guinea pig brain. A marked difference in the developmental profile of these two types of binding sites was observed. The density of central-type receptors gradually increased during embryonic life (especially in cortex and cerebellum), without major changes after birth, while the reverse was true for peripheral-type binding sites. These data contrast with those previously reported in rat, suggesting species differences.

摘要

在豚鼠大脑的3个不同区域研究了“中枢”和“外周”苯二氮䓬（BZ）受体的个体发生发育。观察到这两种结合位点的发育情况存在显著差异。中枢型受体的密度在胚胎期逐渐增加（尤其是在皮质和小脑），出生后无明显变化，而外周型结合位点的情况则相反。这些数据与先前在大鼠中报道的数据形成对比，表明存在物种差异。