环磷酸腺苷——白细胞介素1的细胞内第二信使。
Cyclic AMP--an intracellular second messenger for interleukin 1.
作者信息
Shirakawa F, Yamashita U, Chedid M, Mizel S B
机构信息
Department of Microbiology and Immunology, Wake Forest University Medical Center, Winston-Salem, NC 27103.
出版信息
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8201-5. doi: 10.1073/pnas.85.21.8201.
Abstract
We demonstrated that interleukin 1 (IL-1), a potent peptide mediator in immune and inflammatory responses, stimulates the synthesis of cAMP in a variety of IL-1-responsive cell targets. We also showed that cAMP analogs and cAMP-inducing agents can replace IL-1 in the induction of interleukin 2 receptors on lymphocytes as well as in phytohemagglutinin-induced murine thymocyte proliferation. By use of IL-1 and the cAMP-inducer, forskolin, a direct correlation between the induced level of cAMP and the degree of lymphocyte interleukin 2 receptor expression or thymocyte proliferation was established. Our results indicate that cAMP may be an important intracellular second messenger for IL-1.
摘要
我们证明，白细胞介素1（IL-1）作为免疫和炎症反应中一种有效的肽介质，可刺激多种IL-1反应性细胞靶标中cAMP的合成。我们还表明，cAMP类似物和cAMP诱导剂在诱导淋巴细胞上的白细胞介素2受体以及在植物血凝素诱导的小鼠胸腺细胞增殖中可替代IL-1。通过使用IL-1和cAMP诱导剂毛喉素，建立了诱导的cAMP水平与淋巴细胞白细胞介素2受体表达程度或胸腺细胞增殖程度之间的直接相关性。我们的结果表明，cAMP可能是IL-1的重要细胞内第二信使。
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