Effects of Helicobacter Pylori Colonization/Infection on the Metabolic Profile of Obese Persons Undergoing Sleeve Gastrectomy Surgery for Weight Reduction.

BACKGROUND

Helicobacter pylori (HP) infection of the gastric mucosa may be involved in the development of insulin resistance (IR).

OBJECTIVES

To investigate the association between HP status in stomach biopsies and weight reduction in patients who underwent laparoscopic sleeve gastrectomy (LSG).

METHODS

In this retrospective analysis of medical charts, all patients who underwent LSG for weight reduction and had at least 1 year of follow-up were included. HP status was ascertained by two to four biopsies of the removed stomach.

RESULTS

The study group comprised 70 patients; their mean age was 45.9 ± 11.9 years and 31.9% were males. Fourteen patients (20%) tested positive for HP colonization in gastric mucosa. HP status was not associated with age or smoking status. No difference was noted in the rate of diabetes mellitus (DM) or hypertension, but patients with HP had lower rates of hyperlipidemia (0 vs. 29 patients, 52%, P < 0.001). Patients lost an average of 10.5 kg/m2 after 12 months of follow-up, and no difference was noted between HP-positive and HP-negative patients. The rate of DM control was also similar between HP-positive and HP-negative patients at baseline (33.3 vs. 29.4, P = NS) and at 12 months of follow-up (70% vs. 50%, P = NS).

CONCLUSIONS

HP status was not associated with changes in metabolic profiles and co-morbidity status, or in the efficacy of LSG.