Shimonov Mordechai, Leibou Lior, Davidov Eduard, Bernadsky Olga, Wainstein Julio, Leibovitz Eyal
Department of Surgery A, Wolfson Medical Center, Holon, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Isr Med Assoc J. 2016 Jul;18(7):401-403.
Helicobacter pylori (HP) infection of the gastric mucosa may be involved in the development of insulin resistance (IR).
To investigate the association between HP status in stomach biopsies and weight reduction in patients who underwent laparoscopic sleeve gastrectomy (LSG).
In this retrospective analysis of medical charts, all patients who underwent LSG for weight reduction and had at least 1 year of follow-up were included. HP status was ascertained by two to four biopsies of the removed stomach.
The study group comprised 70 patients; their mean age was 45.9 ± 11.9 years and 31.9% were males. Fourteen patients (20%) tested positive for HP colonization in gastric mucosa. HP status was not associated with age or smoking status. No difference was noted in the rate of diabetes mellitus (DM) or hypertension, but patients with HP had lower rates of hyperlipidemia (0 vs. 29 patients, 52%, P < 0.001). Patients lost an average of 10.5 kg/m2 after 12 months of follow-up, and no difference was noted between HP-positive and HP-negative patients. The rate of DM control was also similar between HP-positive and HP-negative patients at baseline (33.3 vs. 29.4, P = NS) and at 12 months of follow-up (70% vs. 50%, P = NS).
HP status was not associated with changes in metabolic profiles and co-morbidity status, or in the efficacy of LSG.
胃黏膜幽门螺杆菌（HP）感染可能与胰岛素抵抗（IR）的发生有关。
研究接受腹腔镜袖状胃切除术（LSG）患者胃活检中HP状态与体重减轻之间的关联。
在这项病历回顾性分析中，纳入了所有因减重接受LSG且至少随访1年的患者。通过对切除胃进行两到四次活检确定HP状态。
研究组包括70例患者；他们的平均年龄为45.9±11.9岁，男性占31.9%。14例患者（20%）胃黏膜HP定植检测呈阳性。HP状态与年龄或吸烟状况无关。糖尿病（DM）或高血压发病率无差异，但HP阳性患者高脂血症发病率较低（0例对29例，52%，P<0.001）。随访12个月后患者平均体重减轻10.5 kg/m2，HP阳性和HP阴性患者之间无差异。HP阳性和HP阴性患者在基线时（33.3对29.4，P=无统计学意义）和随访12个月时（70%对50%，P=无统计学意义）DM控制率也相似。
HP状态与代谢谱和合并症状态的变化或LSG的疗效无关。
