顺铂配合物包封在自组装环肽二聚体中。
cis-Platinum Complex Encapsulated in Self-Assembling Cyclic Peptide Dimers.
机构信息
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
CIQUP, Department of Chemistry and Biochemistry, Faculdade de Ciencias, Universidade do Porto , 4169-007 Porto, Portugal.
出版信息
Org Lett. 2017 May 19;19(10):2560-2563. doi: 10.1021/acs.orglett.7b00871. Epub 2017 May 4.
PMID:28471680
Abstract
A new cyclic peptide dimer that encapsulates cisplatin complexes in its internal cavity is described. The resulting complex showed cytotoxic activity at A2780 ovarian cancer cell lines independent of acquired platinum resistance.
摘要
一种新的环状二肽分子，其内部空腔可以包裹顺铂配合物。所得复合物在 A2780 卵巢癌细胞系中表现出细胞毒性活性，与获得性铂耐药性无关。
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