Seleem Waseem M, Hanafy Amr S
Department of Internal Medicine, Endoscopy Unit, Division of Gastroenterology and Hepatology, Zagazig University, Zagazig, Egypt.
Eur J Gastroenterol Hepatol. 2017 Aug;29(8):968-972. doi: 10.1097/MEG.0000000000000893.
Gastric varices (GVs) occur with an incidence of 20% in patients with portal hypertension. The aim of this study was to evaluate the efficacy of endoscopic band ligation (BL) as an option in the management of small-to-moderate nonbleeding GVs in cirrhotic patients.
A total of 50 patients (GOV2; n=6, IGV1; n=34, IGV2; n=10) with nonbleeding small-to-moderate-sized GVs without local risk signs of bleeding, such as large size, red-colored elevated areas or red wales, and systemic factors of bleeding risk such as an international normalized ratio of at least 2 and a platelet count of 80 000/µl or less were subjected to endoscopic BL. The patients were followed up every 2 weeks for 1 month and then every 1.5 months for 6 months. The primary outcome was GV eradication, detection of complications such as postprocedural bleeding ulceration and mortality.
The mean number of BL sessions was 2.2±0.8; post-BL ulceration occurred in two (4%) patients (n=2 in IGV1, P=0.61), bleeding occurred in one (2%) patient (n=1 in IGV1, P=0.79), and epigastric pain occurred in six (12%, n=4 in GOV2, n=2 in IGV1) patients. There was no mortality reported among patients treated with BL.
Endoscopic BL resulted in better outcome and a lower incidence of complications when used to treat small-to-medium-sized nonbleeding GVs. Further, early eradication can save effort and cost, thus avoiding the future risk of treatment of large or risky GVs with sclerotherapy.
门静脉高压患者胃静脉曲张(GVs)的发生率为20%。本研究旨在评估内镜下套扎术(BL)作为肝硬化患者中小等大小非出血性GVs治疗方法的疗效。
共有50例患者(GOV2型6例、IGV1型34例、IGV2型10例),患有中小等大小非出血性GVs,无局部出血风险迹象,如大尺寸、红色隆起区域或红色条纹,也无全身出血风险因素,如国际标准化比值至少为2且血小板计数为80000/µl或更低,接受了内镜下BL治疗。患者每2周随访1个月,然后每1.5个月随访6个月。主要结局为GV根除、检测术后出血、溃疡等并发症及死亡率。
BL治疗的平均次数为2.2±0.8次;2例(4%)患者发生BL术后溃疡(IGV1型2例,P=0.61),1例(2%)患者发生出血(IGV1型1例,P=0.79),6例(12%)患者出现上腹部疼痛(GOV2型4例,IGV1型2例)。接受BL治疗的患者中未报告死亡病例。
内镜下BL用于治疗中小等大小非出血性GVs时,疗效更佳,并发症发生率更低。此外,早期根除可节省人力和成本,从而避免未来用硬化疗法治疗大尺寸或有风险的GVs的风险。