Blagburn J M
Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, Old San Juan.
P R Health Sci J. 1988 Aug;7(2):171-6.
The synaptic connection between the filiform hair sensory neurons (FHSNs) and the giant interneurons (GIs) in the terminal abdominal ganglion of the first-instar cockroach Periplaneta americana has been used as a model system for investigating the mechanism of synaptic specificity. Electrophysiological and electron microscopical techniques were used to determine the normal patterns of connectivity between FHSNs and GIs. It was found that, even during synaptogenesis, no incorrect synapses were formed between the sensory axons and the interneuronal dendrites. Studies of a mutant in which there is a supernumerary filiform hair have given an insight into the role of positional information in determining the shape of a sensory neuron, and its connectivity with the GIs. There is electrophysiological evidence for competitive interactions between the supernumerary sensory axon and the original.
在一龄美洲大蠊的腹部末端神经节中，丝状毛感觉神经元（FHSNs）与巨中间神经元（GIs）之间的突触连接已被用作研究突触特异性机制的模型系统。采用电生理和电子显微镜技术来确定FHSNs和GIs之间正常的连接模式。研究发现，即使在突触形成过程中，感觉轴突与中间神经元树突之间也不会形成错误的突触。对一个具有多余丝状毛的突变体的研究，深入了解了位置信息在决定感觉神经元形状及其与GIs连接性方面的作用。有电生理证据表明多余的感觉轴突与原始轴突之间存在竞争性相互作用。
