Frias Mario, Rivero-Juarez Antonio, Tellez Francisco, Perez-Perez Monserrat, Camacho Angela, Machuca Isabel, Lorenzo-Moncada Sandra, Lopez-Lopez Pedro, Rivero Antonio
Infectious Diseases Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain.
Infectious Diseases and Microbiology Unit, Hospital La Línea, AGS Campo de Gibraltar, Cádiz, Spain.
PLoS One. 2017 May 4;12(5):e0177141. doi: 10.1371/journal.pone.0177141. eCollection 2017.
To evaluate the rate of spontaneous resolution of chronic hepatitis C (CHC) infection in a cohort of HIV-infected patients.
A retrospective analysis of 509 HIV-infected patients with chronic HCV infection was performed at two reference hospitals in Andalusia. The main variable of the study was spontaneous clearance of CHC, defined as a negative HCV RNA result after at least two previous quantitative measurements of HCV RNA separated by a minimum of 12 months.
Of 509 patients, 3 (0.59%; 95% CI: 0.15%-1.6%) experienced spontaneous clearance of CHC. After combination antiretroviral therapy (cART) initiation, two of three cases experienced an increased CD4+ count, coinciding with HCV viral clearance. All patients were IL28B CC carriers, 2 were co-infected with HCV genotype 3 (the HCV genotype of the remaining patient was not available).
Spontaneous clearance of CHC is a rare event in the context of HIV/HCV co-infected patients and may be associated with the effective use of cART and thus HIV suppression.
评估一组HIV感染患者中慢性丙型肝炎（CHC）感染的自发清除率。
在安达卢西亚的两家参考医院对509例慢性HCV感染的HIV感染患者进行了回顾性分析。该研究的主要变量是CHC的自发清除，定义为在至少两次先前间隔至少12个月的HCV RNA定量测量后HCV RNA结果为阴性。
在509例患者中，3例（0.59%；95%CI：0.15%-1.6%）出现CHC的自发清除。开始联合抗逆转录病毒治疗（cART）后，三例中有两例CD4+细胞计数增加，同时HCV病毒清除。所有患者均为IL28B CC携带者，2例合并HCV 3型感染（其余患者的HCV基因型信息未提供）。
在HIV/HCV合并感染患者中，CHC的自发清除是一种罕见事件，可能与cART的有效使用及HIV抑制有关。
