罂粟碱类似物的构效关系研究。
A structure-activity relationship study on papaverine analogs.
作者信息
Gupta S P, Garg C, Gupta J K
机构信息
Department of Chemistry, Birla Institute of Technology and Science, India.
出版信息
Res Commun Chem Pathol Pharmacol. 1988 Aug;61(2):265-8.
PMID:2847262
Abstract
The structure-activity relationship of papaverine analogs, the inhibitors of adenosine cyclic 3', 5'-monophosphate (c-AMP) phosphodiesterase, is discussed. The enzyme inhibition activity of these compounds are found to be dominantly controlled by hydrophobicity and steric factors. A significant quantitative correlation has been obtained between the inhibition activity and the van der Waals volume.
摘要
本文讨论了罂粟碱类似物（腺苷环化3'，5'-单磷酸（c-AMP）磷酸二酯酶抑制剂）的构效关系。发现这些化合物的酶抑制活性主要受疏水性和空间因素控制。在抑制活性与范德华体积之间已获得显著的定量相关性。
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