Qian Jun, Song Zhangfa, Lv Yinxiang, Huang Xuefeng, Mao Binliang
Department of Colorectal Surgery, Xinchang People's Hospital, Xinchang, China.
Department of Colorectal Surgery, Xinchang Affiliated Hospital of Wenzhou Medical University, Xinchang, China.
Cell Physiol Biochem. 2017;41(6):2545-2552. doi: 10.1159/000475978. Epub 2017 May 4.
The published literature contains conflicting results regarding the impact of the glutathione S-transferase T1 (GSTT1) null genotype on the susceptibility to inflammatory bowel disease. Therefore, we conducted a meta-analysis of observational studies to assess the association.
We searched four online databases for eligible studies. The odds ratio (OR) with 95% CI was used to assess the gene-disease association. We also performed subgroup analyses by type of inflammatory bowel disease and ethnicity.
There were 16 individual studies from 11 publications included in the analysis. There were 3366 cases with inflammatory bowel disease and 6013 controls. The meta-analysis of all 16 studies showed the GSTT1 null genotype was associated with increased susceptibility to inflammatory bowel disease (OR = 1.98, 95%CI 1.39-2.84, P < 0.001). The subgroup analysis by ethnicity further identified an association between the GSTT1 null genotype and inflammatory bowel disease in Caucasians, Asians, and Africans. The GSTT1 null genotype was associated with both ulcerative colitis (OR = 1.96, P = 0.004) and Crohn's disease (OR = 2.01, P = 0.022). The GSTT1 null genotype was still significantly associated with ulcerative colitis (OR = 1.63, P < 0.0001) and Crohn's disease (OR = 1.40, P = 0.023) after adjusting for study heterogeneity.
The GSTT1 null genotype is significantly associated with an increased susceptibility to inflammatory bowel disease and is a risk factor for both ulcerative colitis and Crohn's disease.
已发表的文献中关于谷胱甘肽S-转移酶T1（GSTT1）缺失基因型对炎症性肠病易感性的影响存在相互矛盾的结果。因此，我们进行了一项观察性研究的荟萃分析以评估这种关联。
我们在四个在线数据库中搜索符合条件的研究。采用比值比（OR）及95%置信区间（CI）来评估基因与疾病的关联。我们还按炎症性肠病类型和种族进行了亚组分析。
分析纳入了来自11篇出版物的16项独立研究。有3366例炎症性肠病患者和6013名对照。对所有16项研究的荟萃分析表明，GSTT1缺失基因型与炎症性肠病易感性增加相关（OR = 1.98，95%CI 1.39 - 2.84，P < 0.001）。按种族进行的亚组分析进一步确定了GSTT1缺失基因型与白种人、亚洲人和非洲人的炎症性肠病之间存在关联。GSTT1缺失基因型与溃疡性结肠炎（OR = 1.96，P = 0.004）和克罗恩病（OR = 2.01，P = 0.022）均相关。在调整研究异质性后，GSTT1缺失基因型仍与溃疡性结肠炎（OR = 1.63，P < 0.0001）和克罗恩病（OR = 1.40，P = 0.023）显著相关。
GSTT1缺失基因型与炎症性肠病易感性增加显著相关，是溃疡性结肠炎和克罗恩病的危险因素。
