Hong Mun-Kun, Wang Jen-Hung, Su Cheng-Chuan, Li Ming-Hsun, Hsu Yung-Hsiang, Chu Tang-Yuan
*Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital; †School of Medicine, Tzu Chi University; ‡Center for Prevention & Therapy of Gynecology Cancers, Buddhist Tzu Chi General Hospital; §Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien; ∥Departments of Clinical Pathology and Anatomic Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi County; ¶Department of Pathology, Buddhist Tzu Chi General Hospital; and Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, Republic of China.
Int J Gynecol Cancer. 2017 Jul;27(6):1247-1255. doi: 10.1097/IGC.0000000000001004.
The aim of this study was to investigate the expression of estrogen receptor α (ERα) and progesterone receptor B (PRB) in the stroma and carcinoma tissues of cervical cancer and their relationship to clinical characteristics and the status of human papillomavirus (HPV) infection.
Expressional levels of ERα and PRB in tissue blocks of 95 cervical carcinomas were independently scored by 2 pathologists. Human papillomavirus DNA, viral load, and genotypes were determined by polymerase chain reaction. Clinical characteristics were reviewed from chart and cancer registry.
Estrogen receptor α and PRB were mainly expressed in the stroma but not in the carcinoma tissues of the cervical cancer, and their expressions were highly correlated. More stromal ERαs were found in early-stage tumors than in advanced-stage tumors. Greater stromal expressions of ERα and PRB were associated with a more favorable prognosis (P = 0.018 and P = 0.004, respectively). The expressions were not related to the differentiation of cancer, the status of HPV infection, the HPV load, or the genotype. In multivariate analysis, stromal ERα and PRB expressions were independently associated with a lower risk of mortality. The adjusted hazard ratios of mortality for low and high expressions of ERα were 0.19 (95% confidential interval [95% CI], 0.04-0.87) and 0.15 (95% CI, 0.03-0.81), respectively, whereas for low and high expressions of PRB hazard ratios were 0.46 (95% CI, 0.19-1.16) and 0.24 (95% CI, 0.06-0.96), respectively.
This study showed that stromal ERα and PRB expressions are independent prognostic indicators of cervical squamous cell carcinoma.
本研究旨在调查雌激素受体α（ERα）和孕激素受体B（PRB）在宫颈癌基质和癌组织中的表达情况，及其与临床特征和人乳头瘤病毒（HPV）感染状态的关系。
由2名病理学家独立对95例宫颈癌组织块中ERα和PRB的表达水平进行评分。通过聚合酶链反应测定人乳头瘤病毒DNA、病毒载量和基因型。从病历和癌症登记处回顾临床特征。
雌激素受体α和PRB主要在宫颈癌的基质中表达，而不在癌组织中表达，且它们的表达高度相关。早期肿瘤中发现的基质ERα比晚期肿瘤更多。ERα和PRB的基质表达较高与更良好的预后相关（分别为P = 0.018和P = 0.004）。这些表达与癌症分化、HPV感染状态、HPV载量或基因型无关。在多变量分析中，基质ERα和PRB表达与较低的死亡风险独立相关。ERα低表达和高表达的死亡调整风险比分别为0.19（95%置信区间[95%CI]，0.04 - 0.87）和0.15（95%CI，0.03 - 0.81），而PRB低表达和高表达的风险比分别为0.46（95%CI，0.19 - 1.16）和0.24（95%CI，0.06 - 0.96）。
本研究表明，基质ERα和PRB表达是宫颈鳞状细胞癌的独立预后指标。
