Jin Zhaokui, Wen Yanyuan, Xiong Liwei, Yang Tian, Zhao Penghe, Tan Liwei, Wang Tianfu, Qian Zhiyong, Su Bao-Lian, He Qianjun
National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China.
Chem Commun (Camb). 2017 May 17;53(40):5557-5560. doi: 10.1039/c7cc01576c.
A new HO-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral HO-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.
一种用于一氧化碳（CO）治疗的新型对过氧化氢（HO）响应的纳米药物，是通过将疏水性羰基锰前药有效包封到先进的中空介孔二氧化硅纳米颗粒载体中构建而成，以实现肿瘤内HO触发的CO释放以及对肿瘤细胞而非正常细胞的选择性杀伤，展现出CO治疗在体外和体内的高效性。
