Chan Winnie Ky, Chang Kai On, Lau Wing Hung
Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong, SAR, Hong Kong.
Eur J Pediatr. 2017 Aug;176(8):1137-1141. doi: 10.1007/s00431-017-2899-7. Epub 2017 May 4.
We report a 16-year-old girl who was diagnosed with acute leukaemia and a marked leucocytosis >200 × 10/L. She presented with marked hypophosphatemia, hypokalemia, acute renal failure and acute respiratory failure. These electrolytes disturbances may indicate rapid tumour genesis. These ominous findings required urgent treatment to halt the crises of rapid leukemic cell proliferation.
Mark hypophosphatemia and hypokalemia may be presenting electrolyte abnormalities in a patient with acute leukaemia, and these may be indicators of aggressive tumour genesis. What is known: • Mild electrolyte disturbances are common in oncology patients • Tumour lysis syndrome is well recognized by paediatriaticians What is new: • Life-threatening hypophosphatemia is an uncommon presentation • These electrolytes disorders may indicate an aggressive tumour genesis process even at presentation and require urgent treatment.
我们报告一名16岁女孩，她被诊断为急性白血病，白细胞显著增多，超过200×10⁹/L。她出现明显的低磷血症、低钾血症、急性肾衰竭和急性呼吸衰竭。这些电解质紊乱可能表明肿瘤快速发生。这些不祥的发现需要紧急治疗以阻止白血病细胞快速增殖的危机。
明显的低磷血症和低钾血症可能是急性白血病患者出现的电解质异常，这些可能是侵袭性肿瘤发生的指标。已知信息：• 轻度电解质紊乱在肿瘤患者中很常见 • 肿瘤溶解综合征为儿科医生所熟知 新发现：• 危及生命的低磷血症是一种不常见的表现 • 这些电解质紊乱即使在疾病初发时也可能表明侵袭性肿瘤发生过程，需要紧急治疗。
