低剂量辐射诱发的脑膜瘤携带NF2基因的结构变异和独特的突变特征。 - Suppr

Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature.

作者信息

Sahm Felix, Toprak Umut H, Hübschmann Daniel, Kleinheinz Kortine, Buchhalter Ivo, Sill Martin, Stichel Damian, Schick Matthias, Bewerunge-Hudler Melanie, Schrimpf Daniel, Zadeh Gelareh, Aldape Ken, Herold-Mende Christel, Beck Katja, Staszewski Ori, Prinz Marco, Harosh Carmit Ben, Eils Roland, Sturm Dominik, Jones David T W, Pfister Stefan M, Paulus Werner, Ram Zvi, Schlesner Matthias, Grossman Rachel, von Deimling Andreas

机构信息

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

出版信息

Acta Neuropathol. 2017 Jul;134(1):155-158. doi: 10.1007/s00401-017-1715-9. Epub 2017 May 4.

DOI:10.1007/s00401-017-1715-9

PMID:28474103

Abstract

摘要

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Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature.低剂量辐射诱发的脑膜瘤携带NF2基因的结构变异和独特的突变特征。

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Comparative analysis of the NF2, TP53, PTEN, KRAS, NRAS and HRAS genes in sporadic and radiation-induced human meningiomas.散发性和辐射诱导性人类脑膜瘤中NF2、TP53、PTEN、KRAS、NRAS和HRAS基因的比较分析

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Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature.

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