Simon P, Pietsch U-C, Oesemann R, Dietrich A, Wrigge H
Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsmedizin Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland.
Integriertes Forschungs- und Behandlungszentrum (IFB) AdipositasErkrankungen, Universitätsmedizin Leipzig, Leipzig, Deutschland.
Anaesthesist. 2017 Jul;66(7):500-505. doi: 10.1007/s00101-017-0314-4. Epub 2017 May 4.
Aspiration of stomach content is a severe complication during general anaesthesia. The DGAI (German Society for Anesthesiology and Intensive Care Medicine) guidelines recommend a fasting period for liquids of 2 h, with a maximum of 400 ml. Preoperative fasting can affect the patients' recovery after surgery due to insulin resistance and higher protein catabolism as a response to surgical stress.
The aim of the study was to compare a liberal fasting regimen consisting of up to 1000 ml of liquids until 2 h before surgery with the DGAI recommendation.
The prospective observational clinical study was approved by the ethics committee of the University of Leipzig. In the liberal fasting group (G) patients undergoing bariatric surgery were asked to drink 1000 ml of tea up to 2 h before surgery. Patients assigned to the restrictive fasting group (G) who were undergoing nonbariatric abdominal surgery were asked to drink no more than 400 ml of water up to 2 h preoperatively. Right after anaesthesia induction and intubation a gastric tube was placed, gastric residual volume was measured and the pH level of gastric fluid was determined. Moreover, the occurrence of aspiration was monitored.
In all, 98 patients with a body mass index (BMI) of G 51.1 kg/m and G 26.5 kg/m were identified. The preoperative fasting period of liquids was significantly different (G 170 min vs. G 700 min, p < 0.001). There was no difference regarding the residual gastric volume (G 11 ml, G 5 ml, p = 0.355). The pH of gastric fluid was nearly similar (G 4.0; G 3.0; p = 0.864). Aspiration did not occur in any patient.
There is evidence suggesting that a liberal fluid fasting regimen (1000 ml of fluid) in the preoperative period is safe in patients undergoing bariatric surgery.
胃内容物误吸是全身麻醉期间的一种严重并发症。德国麻醉与重症医学学会(DGAI)指南建议液体禁食时间为2小时,最多400毫升。术前禁食会因胰岛素抵抗和作为对手术应激反应的更高蛋白质分解代谢而影响患者术后恢复。
本研究的目的是将术前2小时内饮用多达1000毫升液体的宽松禁食方案与DGAI的建议进行比较。
这项前瞻性观察性临床研究得到了莱比锡大学伦理委员会的批准。在宽松禁食组(G组)中,接受减肥手术的患者被要求在手术前2小时内饮用1000毫升茶。分配到严格禁食组(G组)的接受非减肥腹部手术的患者被要求在术前2小时内饮用不超过400毫升水。麻醉诱导和插管后立即放置胃管,测量胃残余量并测定胃液的pH值。此外,监测误吸的发生情况。
总共确定了98例体重指数(BMI)分别为G 51.1 kg/m²和G 26.5 kg/m²的患者。液体的术前禁食时间有显著差异(G组170分钟 vs. G组700分钟,p < 0.001)。胃残余量没有差异(G组11毫升,G组5毫升,p = 0.355)。胃液的pH值几乎相似(G组4.0;G组3.0;p = 0.864)。没有任何患者发生误吸。
有证据表明,术前宽松的液体禁食方案(1000毫升液体)对接受减肥手术的患者是安全的。