Department of Biomedical Sciences, University of Sassari, viale San Pietro 43B, 07100, Sassari, Italy.
J Neurovirol. 2017 Aug;23(4):587-592. doi: 10.1007/s13365-017-0531-2. Epub 2017 May 4.
Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.
人类星形胶质细胞暴露于 HIV-Tat 和/或表皮生长因子 (EGF) 中，以监测内源性逆转录病毒家族的神经致病 MSRV 和 Syncytin-1 元件以及 TNFα 的表达。结果表明，EGF 通过激活 EGFR 来拮抗 Tat 对 HERV-W/MSRVenv/Syncytin-1 的调节；这种作用是通过干扰 Tat 诱导的 TNFα 产生来实现的。EGF 拮抗 Tat 介导的神经致病性 HERV-W 调节的新作用可能具有神经保护作用，但它在大脑中的实际作用仍有待阐明。
