Johnson S W, Teachey A L, Valanejad S M, Griffin S M, Weber S F
Department of Pharmacy, Novant Health Forsyth Medical Center, Winston-Salem, NC, USA.
Department of Pharmacy Practice, Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC, USA.
J Clin Pharm Ther. 2017 Oct;42(5):624-626. doi: 10.1111/jcpt.12547. Epub 2017 May 5.
The impact of gastric bypass surgery on the pharmacokinetics of various medications has been reported. Presently, no data exist for the treatment of chronic hepatitis C virus with ledipasvir/sofosbuvir (LDV/SOF) in an individual with a history of gastric bypass.
We report the successful cure of an individual who was treated with LDV/SOF who had a history of gastric bypass. The patient tolerated LDV/SOF well while only experiencing a minor headache.
Ledipasvir/sofosbuvir treatment may still be effective in those with a history of gastric bypass surgery.
已有报道称胃旁路手术对多种药物的药代动力学有影响。目前，尚无关于曾接受胃旁路手术的个体使用来迪派韦/索磷布韦（LDV/SOF）治疗慢性丙型肝炎病毒的数据。
我们报告了一例有胃旁路手术史的患者使用LDV/SOF治疗成功治愈的病例。该患者对LDV/SOF耐受性良好，仅出现轻微头痛。
对于有胃旁路手术史的患者，来迪派韦/索磷布韦治疗可能仍然有效。
