Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
College of Nursing, University of Raparin, Kurdistan Region, Iraq.
Immun Inflamm Dis. 2017 Jun;5(2):151-162. doi: 10.1002/iid3.154. Epub 2017 Mar 13.
Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity.
We analyzed female LDLR and LDLR mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation.
The groups on a high fat high sugar diet with supplementary Vitamin D , in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there was less pericentral hepatic steatosis. Levels of non-esterified fatty acids and lipid peroxidation products were significantly lower in the group supplemented with additional Vitamin D , as were systemic markers of inflammation (serum endotoxin and IL-6). M2 macrophage phenotype predominated in the group supplemented with additional Vitamin D . Beneficial changes were observed as early as five weeks' supplementation with Vitamin D and extended to restoration of high fat high sugar diet induced decrease of bone mineral density.
In summary, Vitamin D was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR and LDLR mice.
脂肪肝疾病在高热量摄入的人群中普遍存在。人们正在考虑营养治疗方法，如补充维生素 D，以改善代谢综合征的各个方面，即脂肪肝疾病、高脂血症和与肥胖相关的胰岛素抵抗。
我们分析了 LDLR 和 LDLR 雌性小鼠在 10 周致糖尿病饮食下的脂肪肝疾病、代谢应激和炎症标志物。
与单独高脂肪高糖饮食组相比，补充维生素 D 的高脂肪高糖饮食组的转氨酶水平改善，明显较少出现高甘油三酯血症和高胰岛素血症，组织学上肝中心周围脂肪变性也较少。补充额外维生素 D 的组中非酯化脂肪酸和脂质过氧化产物的水平显著降低，全身性炎症标志物（血清内毒素和 IL-6）也是如此。补充额外维生素 D 的组中 M2 巨噬细胞表型占主导地位。早在补充维生素 D 五周后就观察到有益的变化，并扩展到恢复高脂肪高糖饮食诱导的骨密度降低。
总之，维生素 D 是一种显著有益的饮食添加剂，可以减轻 LDLR 和 LDLR 雌性小鼠饮食诱导肥胖的糖尿病前期表型。
