海胆色素的可能降血糖机制。
The Possible Hypoglycemic Mechanisms of Echinochrome.
作者信息
Mohamed Ayman Saber, Soliman Amel Mahmoud, Marie Mohamed-Assem Said
机构信息
Zoology Department, Faculty of Science, Cairo University, 12613, Giza, Egypt.
出版信息
Curr Diabetes Rev. 2018;14(4):334-338. doi: 10.2174/1573399813666170505120119.
BACKGROUND
Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.
OBJECTIVE
In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.
CONCLUSION
The hypoglycemic effect of echinochrome involving four main pathways; regeneration of pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.
背景
糖尿病是全球发病和死亡的主要原因。近年来，天然产物因其潜在的药理用途而备受关注。海胆紫酮是一种从海胆中分离出的天然化合物，具有多种生物学效应。最近许多实验报道了海胆紫酮的降血糖活性。
目的
在我们的研究中，我们试图收集海胆紫酮所有可能的降血糖机制。
结论
海胆紫酮的降血糖作用涉及四个主要途径；胰腺再生、降低胰岛素抵抗、增加胰岛素分泌和改善葡萄糖稳态。
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