Moon Ik Jun, Kang Hyun Ji, Lee Mi Woo, Lee Woo Jin
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Indian J Dermatol Venereol Leprol. 2017 Jul-Aug;83(4):453-456. doi: 10.4103/ijdvl.IJDVL_264_16.
Natural killer/T-cell lymphoma is a rare, Epstein-Barr virus-associated type of cytotoxic lymphoma thatpresents mainly in the nasal cavity and its vicinity. Very few cases of primary cutaneous extranodal natural killer/T-cell lymphoma have been reported till date. All the previously reported cases of primary cutaneous extranodalnatural killer/T-cell lymphoma presented as lesions resembling cellulitis, subcutaneous nodules or ulcers. We report a rare case which presented as erythematous and purpuric round patches on the arms and was finally diagnosed as primary cutaneous extranodalnatural killer/T-cell lymphoma, following a skin biopsy. The atypical patchy lesions presented a diagnostic challenge. We herein describe this clinically novel atypical patch-like presentation of primary cutaneous extranodalnatural killer/T-cell lymphoma together with the key histopathologic features and highlights of the previously reported cases.
自然杀伤/T细胞淋巴瘤是一种罕见的、与EB病毒相关的细胞毒性淋巴瘤,主要发生在鼻腔及其附近。迄今为止,原发性皮肤结外自然杀伤/T细胞淋巴瘤的病例报道极少。所有先前报道的原发性皮肤结外自然杀伤/T细胞淋巴瘤病例均表现为类似蜂窝织炎、皮下结节或溃疡的病变。我们报告一例罕见病例,该病例表现为手臂上的红斑和紫癜性圆形斑块,经皮肤活检最终诊断为原发性皮肤结外自然杀伤/T细胞淋巴瘤。这些非典型斑块样病变带来了诊断挑战。我们在此描述原发性皮肤结外自然杀伤/T细胞淋巴瘤这种临床上新颖的非典型斑块样表现,以及关键的组织病理学特征和先前报道病例的要点。