Wang Lan, Kang Xiaojiao, Pan Daocheng
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Road, Changchun, Jilin 130022, P. R. China.
University of the Chinese Academy of Sciences , Beijing 10049, P. R. China.
Inorg Chem. 2017 Jun 5;56(11):6122-6130. doi: 10.1021/acs.inorgchem.7b00053. Epub 2017 May 5.
Assisted with polyethylenimine, 4.0 L of water-soluble AgInS quantum dots (AIS QDs) were successfully synthesized in an electric pressure cooker. As-prepared QDs exhibit yellow emission with a photoluminescence (PL) quantum yield up to 32%. The QDs also show excellent water/buffer stability. The highly luminescent AIS QDs are used to explore their dual-functional behavior: detection of hydrogen peroxide (HO)/glucose and cell imaging. The amino-functionalized AIS QDs show high sensitivity and specificity for HO and glucose with detection limits of 0.42 and 0.90 μM, respectively. A linear correlation was established between PL intensity and concentration of HO in the ranges of 0.5-10 μM and 10-300 μM, while the linear ranges were 1-10 μM and 10-1000 μM for detection of glucose. The AIS QDs reveal negligible cytotoxicity on HeLa cells. Furthermore, the luminescence of AIS QDs gives the function of optical imaging.
在聚乙烯亚胺的辅助下，在高压锅中成功合成了4.0升水溶性AgInS量子点（AIS量子点）。所制备的量子点呈现黄色发射，光致发光（PL）量子产率高达32%。这些量子点还表现出优异的水/缓冲稳定性。高发光的AIS量子点被用于探索其双功能行为：检测过氧化氢（HO）/葡萄糖以及细胞成像。氨基功能化的AIS量子点对HO和葡萄糖表现出高灵敏度和特异性，检测限分别为0.42和0.90 μM。在0.5 - 10 μM和10 - 300 μM范围内，PL强度与HO浓度之间建立了线性相关性，而检测葡萄糖时的线性范围为1 - 10 μM和10 - 1000 μM。AIS量子点对HeLa细胞显示出可忽略不计的细胞毒性。此外，AIS量子点的发光赋予了光学成像功能。
