Jacobson Amanda E, Kahwash Samir B, Chawla Anjulika
Division of Pediatric Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, Ohio.
Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio.
Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26617. Epub 2017 May 5.
Copper deficiency is a known cause of anemia and neutropenia that is easily remedied with copper supplementation. Copper is primarily absorbed in the stomach and proximal duodenum, so patients receiving enteral nutrition via methods that bypass this critical region may be at increased risk for copper deficiency. In pediatrics, postpyloric enteral feeding is increasingly utilized to overcome problems related to aspiration, severe reflux, poor gastric motility, and gastric outlet obstruction. However, little is known about the prevalence of copper deficiency in this population. We describe three pediatric patients receiving exclusive jejunal feeds who developed cytopenias secondary to copper deficiency.
铜缺乏是贫血和中性粒细胞减少症的已知病因，通过补充铜很容易得到纠正。铜主要在胃和十二指肠近端被吸收，因此通过绕过这一关键区域的方法接受肠内营养的患者可能有更高的铜缺乏风险。在儿科，幽门后肠内喂养越来越多地被用于克服与误吸、严重反流、胃动力差和胃出口梗阻相关的问题。然而，对于这一人群中铜缺乏的患病率知之甚少。我们描述了三名接受空肠全肠内营养的儿科患者，他们因铜缺乏而出现血细胞减少。
