Kaneshima Tai, Myoda Takao, Toeda Kazuki, Fujimori Takane, Nishizawa Makoto
a Department of Food and Cosmetic Science , Tokyo University of Agriculture , Abashiri , Japan.
Biosci Biotechnol Biochem. 2017 Aug;81(8):1461-1465. doi: 10.1080/09168451.2017.1320517. Epub 2017 May 5.
Various antimicrobial constituents of camu-camu fruit were isolated. Acylphloroglucinol (compound 1) and rhodomyrtone (compound 2) were isolated from the peel of camu-camu (Myrciaria dubia) fruit, while two other acylphloroglucinols (compounds 3 and 4) were obtained from camu-camu seeds. The structures of the isolated compounds were characterized by spectrophotometric methods. Compounds 1 and 4 were confirmed to be new acylphloroglucinols with different substituents at the C7 or C9 position of 2, and were named myrciarone A and B, respectively. Compound 3 was determined to be isomyrtucommulone B. This is the first report of the isolation of 3 from a natural resource. The antimicrobial activities of compounds 1, 3, and 4 were similar to those of 2, and the minimum inhibitory concentrations were either similar to or lower than that of kanamycin. These results suggest that the peel and seeds of camu-camu fruit could be utilized for therapeutic applications.
已从卡姆果中分离出多种抗菌成分。从卡姆果（Myrciaria dubia）的果皮中分离出了酰基间苯三酚（化合物1）和玫红菌素（化合物2），而从卡姆果种子中获得了另外两种酰基间苯三酚（化合物3和4）。通过分光光度法对分离出的化合物结构进行了表征。化合物1和4被确认为在2的C7或C9位置具有不同取代基的新型酰基间苯三酚，分别命名为桃金娘酮A和B。化合物3被确定为异香桃木酮B。这是首次从天然资源中分离出3的报道。化合物1、3和4的抗菌活性与2相似，最低抑菌浓度与卡那霉素相似或更低。这些结果表明，卡姆果的果皮和种子可用于治疗应用。
