de Oliveira Gamba Conrado, Scaratti Dirceu, de Andrade Victor Piana, Estrela-Lima Alessandra, Ferreira Enio, Cassali Geovanni Dantas
Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Minas Gerais 31270-901, Brazil.
Departamento de Ciências Exatas e da Terra, Universidade do Oeste de Santa Catarina (UNOESC), Rua Paese 198, Videira, Santa Catarina 89560-000, Brazil.
Res Vet Sci. 2017 Dec;115:189-194. doi: 10.1016/j.rvsc.2017.04.012. Epub 2017 Apr 20.
Invasive micropapillary carcinoma (IMPC) is a breast cancer with a proclivity for lymph node metastasis that affects women. In canines, this carcinoma has only recently been reported and appears to have similar histological aspects as its human counterpart. Thus, the aim of the present study was to compare clinicopathological, immunohistochemical and prognostic characteristics of mammary IMPC between humans and canines. In canines, regional metastasis was more frequently observed. Histopathologically, humans and canines predominantly showed a moderate histological grade. The pure subtype and neoplastic emboli were more frequently observed in canines. Regarding immunohistochemical evaluation, most canine and human IMPCs were positive for the estrogen and progesterone receptors. A reversed pattern of epithelial membrane antigen expression and a high proliferation index predominated in both species. The mortality due to the neoplastic disease was more frequently observed in canines (94%) than in humans (4%). Thus, canine IMPCs show a larger tumor size and higher rates of the pure subtype, regional metastasis and mortality than their human counterparts and appear to provide a good spontaneous model for achieving a better understanding of the biological behavior of human IMPCs.
浸润性微乳头状癌（IMPC）是一种易发生淋巴结转移的乳腺癌，多见于女性。在犬类中，这种癌症最近才被报道，其组织学特征似乎与其人类对应物相似。因此，本研究的目的是比较人类和犬类乳腺IMPC的临床病理、免疫组化和预后特征。在犬类中，区域转移更为常见。组织病理学上，人类和犬类主要表现为中度组织学分级。在犬类中，纯亚型和肿瘤栓子更为常见。关于免疫组化评估，大多数犬类和人类IMPC的雌激素和孕激素受体呈阳性。两种物种中，上皮膜抗原表达的相反模式和高增殖指数占主导。与人类（4%）相比，犬类（94%）因肿瘤疾病导致的死亡率更高。因此，犬类IMPC比人类IMPC表现出更大的肿瘤大小、更高的纯亚型、区域转移和死亡率，似乎为更好地理解人类IMPC的生物学行为提供了一个良好的自发模型。
