Boyd N F, Clemens J D, Feinstein A R
Arch Intern Med. 1979 Mar;139(3):324-8.
To classify the clinical severity of acute leukemia, we have used the degrees of pretherapeutic infection and hemorrhage to construct a taxonomy containing three "stages". The stages are associated with survival gradients that are clinically and statistically distinctive in both acute lymphoblastic leukemia and acute nonlymphoblastic leukemia. Median survival ranged from 64.0 months for stage 1 to 10.5 months for stage 3 in acute lymphoblastic leukemia, and from 7.1 months for stage 1 to 1.2 months for stage 3 in acute nonlymphoblastic leukemia. The gradients, which persist when other prognostic factors and secular therapeutic changes are taken into account, are more distinctive than those found with other forms of stratification.
为了对急性白血病的临床严重程度进行分类，我们利用治疗前感染和出血的程度构建了一个包含三个“阶段”的分类法。这些阶段与生存梯度相关，在急性淋巴细胞白血病和急性非淋巴细胞白血病中，其在临床和统计学上都具有显著差异。在急性淋巴细胞白血病中，1期的中位生存期为64.0个月，3期为10.5个月；在急性非淋巴细胞白血病中，1期的中位生存期为7.1个月，3期为1.2个月。当考虑到其他预后因素和长期治疗变化时，这些梯度仍然存在，且比其他分层形式所发现的梯度更为显著。
