Fujisawa M, Yoshida S, Matsumoto O, Kojima K, Kamidono S
Department of Urology, Kobe University School of Medicine, Japan.
Arch Androl. 1988;21(1):45-50. doi: 10.3109/01485018808986732.
Topoisomerase I, which is involved in DNA metabolism, was measured in the testes of 37 infertile men with varicocele, using a minute amount of testicular biopsy specimen. In 38% of infertile men topoisomerase I activity was lower than that of normal men. Forty-six percent of patients with high grade varicocele (grade III) showed reduced topoisomerase I activity, while only 26% of patients with low grade varicocele (grades I and II) showed reduced levels of topoisomerase I. Johnsen's score of the patients with low topoisomerase I activity was lower than that of patients with normal levels of topoisomerase I. The decrease of topoisomerase I activity may be correlated with at least some fraction of hypospermatogenesis associated with varicocele.
参与DNA代谢的拓扑异构酶I，是通过使用微量睾丸活检标本，在37名患有精索静脉曲张的不育男性的睾丸中进行测量的。在38%的不育男性中，拓扑异构酶I的活性低于正常男性。46%的重度精索静脉曲张（III级）患者表现出拓扑异构酶I活性降低，而轻度精索静脉曲张（I级和II级）患者中只有26%表现出拓扑异构酶I水平降低。拓扑异构酶I活性低的患者的约翰森评分低于拓扑异构酶I水平正常的患者。拓扑异构酶I活性的降低可能至少与部分与精索静脉曲张相关的精子发生减少有关。
