Healy D L, Burger H G
Aust N Z J Obstet Gynaecol. 1978 Nov;18(4):242-6. doi: 10.1111/j.1479-828x.1978.tb00062.x.
A triplet and a quadruplet pregnancy following induction of ovulation with clomiphene are described; in each patient secondary amenorrhoea followed oral contraceptive use and several anovulatory or inadequate menstrual cycles had occurred on initial clomiphene therapy. Conception occurred in the first cycle after increasing drug dosage or the addition of human chorionic gonadotrophin (HCG) to the treatment regimen. We suggest, in explanation of these pregnancies, that repeated suboptimal stimulation of the ovaries as a result of clomiphene therapy develops several follicles to a critical stage; a subsequent greater ovulatory stimulus allows for synchronous development of several large follicles and multiple ovulation.
本文描述了使用克罗米芬诱导排卵后出现的三胎妊娠和四胎妊娠；每位患者在使用口服避孕药后出现继发性闭经，且在初始克罗米芬治疗时发生了几次无排卵或月经周期不规律的情况。受孕发生在增加药物剂量或在治疗方案中添加人绒毛膜促性腺激素（HCG）后的第一个周期。我们认为，对于这些妊娠的解释是，克罗米芬治疗导致卵巢反复受到次优刺激，使多个卵泡发育到关键阶段；随后更大的排卵刺激促使几个大卵泡同步发育并发生多卵泡排卵。
