假血管瘤样多形性/梭形细胞脂肪瘤的细胞遗传学分析

Cytogenetic Analysis of a Pseudoangiomatous Pleomorphic/Spindle Cell Lipoma.

作者信息

Panagopoulos Ioannis, Gorunova Ludmila, Lobmaier Ingvild, Andersen Hege Kilen, Bjerkehagen Bodil, Heim Sverre

机构信息

Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

出版信息

Anticancer Res. 2017 May;37(5):2219-2223. doi: 10.21873/anticanres.11557.

DOI:10.21873/anticanres.11557

PMID:28476785

Abstract

BACKGROUND

Pseudoangiomatous pleomorphic/spindle cell lipoma is a rare subtype of pleomorphic/spindle cell lipoma. Only approximately 20 such tumors have been described. Genetic information on pseudoangiomatous pleomorphic/spindle cell lipoma is restricted to a single case in which deletion of the forkhead box O1 (FOXO1) gene was found, using fluorescence in situ hybridization (FISH).

MATERIALS AND METHODS

G-banding and FISH analyses were performed on a pseudoangiomatous pleomorphic/spindle cell lipoma.

RESULTS

G-banding of tumor cells showed complex karyotypic changes including loss of chromosome 13. FISH analysis revealed that the deleted region contained the RB1 gene (13q14.2) and the part of chromosome arm 13q (q14.2-q14.3) in which spans the TRIM13 gene, the two non-coding RNA genes, DLEU1 and DLEU2, and the genetic markers RH44686 and D13S25.

CONCLUSION

Several acquired genomic aberrations were found in the tumor. Among them was loss of chromosome 13 material. Results confirm the (cyto)genetic similarity between pseudoangiomatous pleomorphic/spindle cell lipoma and spindle cell lipomas.

摘要