性别在极早产儿发病和死亡中的作用。
Role of sex in morbidity and mortality of very premature neonates.
作者信息
Ito Masato, Tamura Masanori, Namba Fumihiko
机构信息
Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Department of Pediatrics, Akita University School of Medicine, Akita City, Akita, Japan.
出版信息
Pediatr Int. 2017 Aug;59(8):898-905. doi: 10.1111/ped.13320. Epub 2017 Jul 14.
BACKGROUND
The aim of this study was to investigate the effect of sex on survival and short-term outcomes of very low-birthweight infants (VLBWI) born in Japan.
METHODS
This study included VLBWI who were admitted to neonatal intensive care units participating in the Neonatal Research Network of Japan, between 2003 and 2012. The primary outcome was a composite of mortality or any major morbidity, including neurologic injury, bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), or retinopathy of prematurity requiring treatment.
RESULTS
The composite primary outcome was worse in male infants. Male infants were also more likely to develop BPD. This difference reached statistical significance in neonates born at ≥26 weeks of gestation. In contrast, significant difference in the incidence of NEC was more likely to be seen at 23-25 weeks of gestation.
CONCLUSION
Male neonates are more likely to die and are at a higher risk of respiratory and gastrointestinal complications than female neonates.
背景
本研究旨在调查性别对在日本出生的极低出生体重儿（VLBWI）生存及短期预后的影响。
方法
本研究纳入了2003年至2012年间入住参与日本新生儿研究网络的新生儿重症监护病房的极低出生体重儿。主要结局是死亡或任何严重疾病的综合情况，包括神经损伤、支气管肺发育不良（BPD）、坏死性小肠结肠炎（NEC）或需要治疗的早产儿视网膜病变。
结果
男性婴儿的综合主要结局更差。男性婴儿也更易患支气管肺发育不良。这种差异在妊娠≥26周出生的新生儿中具有统计学意义。相比之下，坏死性小肠结肠炎发病率的显著差异更可能出现在妊娠23 - 25周时。
结论
与女性新生儿相比，男性新生儿死亡可能性更大，发生呼吸和胃肠道并发症的风险更高。
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