Grishin E V, Volkova T M, Arsen'ev A S
Bioorg Khim. 1988 Jul;14(7):883-92.
Homologous low molecular weight compounds blocking postsynaptic glutamate receptors were isolated from the Argiope lobata spider venom by ion-exchange chromatography and reverse-phase HPLC. Structures of nine different blocking agents were determined by NMR and mass spectroscopy. They can be divided into three groups: argiopin, argiopinins and pseudoargiopinines. The major principles of the structural organization of the novel class of antagonists of glutamate receptors were considered.
通过离子交换色谱法和反相高效液相色谱法，从大腹园蛛毒液中分离出了阻断突触后谷氨酸受体的同源低分子量化合物。通过核磁共振和质谱法确定了九种不同阻断剂的结构。它们可分为三组：蛛毒平、蛛毒平宁和假蛛毒平宁。探讨了这类新型谷氨酸受体拮抗剂结构组织的主要原理。
