Qi Xue Tao, Zhan Jiang Shan, Xiao Li Ming, Li Lina, Xu Han Xiao, Fu Zi Bing, Zhang Yan Hao, Zhang Jing, Jia Xi Hua, Ge Guo, Chai Rui Chao, Gao Kai, Yu Albert Cheung Hoi
Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.
Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Neurochem Res. 2017 Jun;42(6):1847-1863. doi: 10.1007/s11064-017-2272-2. Epub 2017 May 6.
Cell migration is identified as a highly orchestrated process. It is a fundamental and essential phenomenon underlying tissue morphogenesis, wound healing, and immune response. Under dysregulation, it contributes to cancer metastasis. Brain is considered to be the most complex organ in human body containing many types of neural cells with astrocytes playing crucial roles in monitoring both physiological and pathological functions. Astrocytoma originates from astrocytes and its most malignant type is glioblastoma multiforme (WHO Grade IV astrocytoma), which is capable to infiltrate widely into the neighboring brain tissues making a complete resection of tumors impossible. Very recently, we have reviewed the mechanisms for astrocytes in migration. Given the fact that astrocytoma shares many histological features with astrocytes, we therefore attempt to review the mechanisms for glioma cells in migration and compare them to normal astrocytes, hoping to obtain a better insight into the dysregulation of migratory mechanisms contributing to their metastasis in the brain.
细胞迁移被认为是一个高度协调的过程。它是组织形态发生、伤口愈合和免疫反应背后的一种基本且重要的现象。在调节异常的情况下，它会导致癌症转移。大脑被认为是人体中最复杂的器官，包含多种类型的神经细胞，其中星形胶质细胞在监测生理和病理功能方面发挥着关键作用。星形细胞瘤起源于星形胶质细胞，其最恶性的类型是多形性胶质母细胞瘤（世界卫生组织IV级星形细胞瘤），它能够广泛浸润到邻近的脑组织中，使得肿瘤无法完全切除。最近，我们已经综述了星形胶质细胞迁移的机制。鉴于星形细胞瘤与星形胶质细胞具有许多组织学特征，因此我们试图综述胶质瘤细胞迁移的机制，并将它们与正常星形胶质细胞进行比较，希望能更好地了解导致它们在大脑中转移的迁移机制失调情况。
