Dashevskiy Andriy, Mohylyuk Valentyn, Ahmed Abid Riaz, Kolter Karl, Guth Felicitas, Bodmeier Roland
a College of Pharmacy , Freie Universität Berlin , Berlin , Germany.
b Department of Pharmacy, School of Life and Medical Sciences , University of Hertfordshire , Hatfield , UK.
Drug Dev Ind Pharm. 2017 Sep;43(9):1548-1556. doi: 10.1080/03639045.2017.1323910. Epub 2017 May 16.
The objective of this study was to develop delivery systems for taste masking based on multiparticulates coated with Kollicoat Smartseal 30D formulated as liquid oral suspensions. Coating of particles containing bitter drugs with Kollicoat Smartseal reduced drug leaching into aqueous medium, especially when increasing pH, therefore can be used for the formulation of liquid dosage forms. Application of an intermediate layer of ion exchange resins between drug layer and coating can further decrease drug leaching into aqueous vehicle that is beneficial in terms of taste masking. Using optimized compositions of liquid vehicles such as addition of sugar alcohols and ion exchange resin, reconstitutable or ready-to-use liquid dosage forms with micropellets can be developed with bitter taste protection after redispersion lasting longer than 3 weeks, which exceeds the usual period of application.
本研究的目的是开发基于用Kollicoat Smartseal 30D包衣的多颗粒制剂的掩味给药系统，将其制成液体口服混悬剂。用Kollicoat Smartseal包衣含苦味药物的颗粒可减少药物向水性介质中的渗漏，尤其是在提高pH值时，因此可用于液体剂型的制剂。在药物层和包衣之间应用离子交换树脂中间层可进一步减少药物向水性载体中的渗漏，这在掩味方面是有益的。通过使用优化的液体载体组合物，如添加糖醇和离子交换树脂，可以开发出具有微丸的可重构或即用型液体剂型，其在重新分散后具有苦味保护，持续时间超过3周，这超过了通常的应用期限。
