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棘白菌素类药物治疗下由顶头孢霉引起的尿路感染的一个不寻常病例。

An unusual case of urinary tract infection caused by Saprochaete capitata under anidulafungin treatment.

机构信息

Medical microbiology, Ankara Numune training and research hospital, Ulku Mahallesi Talatpasa Bulvari No. 5 Altindag, 06100 Ankara, Turkey.

Clinical microbiology and infectious disease department, Ankara Numune training and research hospital, Ulku Mahallesi Talatpasa Bulvari, No. 5 Altindag, 06100 Ankara, Turkey.

出版信息

J Mycol Med. 2017 Sep;27(3):387-390. doi: 10.1016/j.mycmed.2017.04.001. Epub 2017 May 3.

Abstract

Saprochaete capitata may cause uncommon severe infections, especially in immunocompromised patients. Here, we describe a rare case of urinary tract infection by S. capitata in a chronic kidney disease and diabetes mellitus patient, which occur during anidulafungin therapy. Mycological examinations of urine were positive to S. capitata identified by mass spectrometry and confirmed by ITS sequencing. Minimum inhibitory concentration (MIC) of the isolate for amphotericin B, fluconazole, itraconazole, voriconazole and, anidulafungin were 2, 16, 1, 1, and 8μg/mL, respectively. Presence of S. capitata infection was not known. Clinicians should be aware about these rare opportunistic fungal pathogens, particularly those with intrinsic or variable resistance to antifungals including echinocandins.

摘要

Saprochaete capitata 可能引起罕见的严重感染,特别是在免疫功能低下的患者中。在这里,我们描述了一例慢性肾脏病和糖尿病患者在使用安尼芬净治疗期间发生的 S. capitata 尿路真菌感染的罕见病例。尿的真菌学检查阳性,经质谱和 ITS 测序鉴定为 S. capitata。该分离株对两性霉素 B、氟康唑、伊曲康唑、伏立康唑和安尼芬净的最小抑菌浓度(MIC)分别为 2、16、1、1 和 8μg/mL。S. capitata 感染的存在尚不清楚。临床医生应注意这些罕见的机会性真菌病原体,特别是那些对包括棘白菌素类在内的抗真菌药物具有固有或可变耐药性的病原体。

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