Shibuya Kazumoto
Department of Neurology, Graduate School of Medicine, Chiba University.
Brain Nerve. 2017 May;69(5):565-569. doi: 10.11477/mf.1416200783.
In the late 19th century, Charcot examined patients with amyotrophic lateral sclerosis (ALS) and concluded that the sclerosis in the lateral columns of the spinal cord induced the loss of neurons in the anterior horns. The reason for this remains unknown. In contrast, hyperexcitability of motor neurons is believed to be one of the pathogenetic factors for motor neuron death in ALS. In this article, I have reviewed the relationship between motor neuron hyperexcitability and motor neuron death and considered the mechanism of ALS pathogenesis.
19世纪后期，夏科对肌萎缩侧索硬化症（ALS）患者进行了检查，并得出结论：脊髓侧柱的硬化导致前角神经元的丧失。其原因尚不清楚。相比之下，运动神经元的过度兴奋被认为是ALS中运动神经元死亡的致病因素之一。在本文中，我回顾了运动神经元过度兴奋与运动神经元死亡之间的关系，并探讨了ALS发病机制。
