Heba Mahi, Faraz Sana, Banerjee Sugato
Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.
Pharmacogn Mag. 2017 Jan;13(Suppl 1):S148-S153. doi: 10.4103/0973-1296.203976. Epub 2017 Apr 7.
Alcohol addiction is a worldwide problem. It has mainly two components: dependence and withdrawal. Characteristic properties of most anti-addictive compounds include anti-anxiety, anticonvulsant, antidepressant, and nootropic actions. Shankhpushpi (. Convolvulaceae), known ethnopharmacologically as brain tonic, possess all the properties mentioned above. Here, we screen shankhpushpi for possible anti-addictive potential. Effect of shankhpushpi churna was measured on ethanol withdrawal anxiety using elevated plus maze. The role of shankhpushpi on chronic ethanol consumption (21 days) was measured using two bottle choice protocol of voluntary drinking. We also measured the effect of the above herb on cortico-hippocampal GABA levels. Shankhpushpi was found to reduce alcohol withdrawal anxiety in a dose-dependent manner. The herb also decreased ethanol intake and increased water intake significantly ( < 0.001) after 4 days of administration. Both these effects were blocked ( < 0.001) by GABAA antagonist suggesting the role of GABAA receptor. Chronic administration of shankhpushpi also significantly ( < 0.01) increased cortico-hippocampal GABA levels in mice. Shankhpushpi reduced both alcohol dependence and withdrawal in a GABAA-dependent manner, thus showing anti-addictive potential.
Shankhpushpi prevented ethanol withdrawal anxiety and alcohol addiction in a GABA-dependent manner. GABA: Gamma-Aminobutyric Acid, HIV: Human Immunodeficiency Virus, CNS: Central Nervous System.
酒精成瘾是一个全球性问题。它主要有两个组成部分：依赖和戒断。大多数抗成瘾化合物的特性包括抗焦虑、抗惊厥、抗抑郁和益智作用。从民族药理学角度被称为补脑剂的旋花科植物（Shankhpushpi）具有上述所有特性。在此，我们筛选Shankhpushpi的潜在抗成瘾作用。使用高架十字迷宫测量Shankhpushpi药粉对乙醇戒断焦虑的影响。使用自愿饮酒的双瓶选择方案测量Shankhpushpi对慢性乙醇消耗（21天）的作用。我们还测量了上述草药对皮质-海马γ-氨基丁酸（GABA）水平的影响。发现Shankhpushpi以剂量依赖性方式减轻酒精戒断焦虑。给药4天后，该草药还显著降低了乙醇摄入量并增加了水摄入量（P<0.001）。这两种作用均被GABAA拮抗剂阻断（P<0.001），提示GABAA受体的作用。长期给予Shankhpushpi还显著（P<0.01）提高了小鼠皮质-海马GABA水平。Shankhpushpi以GABAA依赖的方式减轻酒精依赖和戒断，从而显示出抗成瘾潜力。
Shankhpushpi以GABA依赖的方式预防乙醇戒断焦虑和酒精成瘾。GABA：γ-氨基丁酸，HIV：人类免疫缺陷病毒，CNS：中枢神经系统。
