Potigumjon Artit, Watcharakorn Arvemas, Dharmasaroja Pornpatr A
Department of Internal Medicine, Faculty of Medicine, Thammasat University, Thailand.
Department of Radiology, Faculty of Medicine, Thammasat University, Thailand.
J Neurosci Rural Pract. 2017 Apr-Jun;8(2):216-220. doi: 10.4103/0976-3147.203836.
With the widespread use of magnetic resonance imaging (MRI), cerebral microbleeds (CMBs) are commonly detected. Ethnicity seems to play a role in the prevalence of CMB, with higher prevalence in participants from Asian origin. The purpose of the study is to look for the prevalence of CMBs and associated factors in Thai patients with ischemic stroke.
Patients with acute ischemic stroke who had MRI and magnetic resonance angiography during January-August 2014 were included in the study. T2*-weighted gradient-recalled echo was used to define CMBs. Baseline characteristics, stroke subtypes, and severity of white matter lesions were compared between patients with and without CMBs.
Two hundred patients were included in the study. Mean age of the patients was 61-year-old. Mean National Institutes of Health Stroke Scale was 8. The prevalence of CMBs was 20% (39/200 patients). Hypertension (odds ratio [OR] 3.05, 95% confidence interval [CI] 1.07-8.68, = 0.037), and moderate-to-severe white matter lesions (Fazekas 2-3, OR 7.61, 95% CI 3.06-18.95, < 0.001) were related to the presence of CMBs.
CMBs were found in 20% of patients with ischemic stroke, which was lower than those reported from Japanese studies but comparable to a Chinese study. CMBs were associated with hypertension and severity of the white matter lesions.
随着磁共振成像（MRI）的广泛应用，脑微出血（CMBs）常被检测到。种族似乎在CMB的患病率中起作用，亚洲裔参与者的患病率较高。本研究的目的是寻找泰国缺血性中风患者中CMB的患病率及相关因素。
纳入2014年1月至8月期间进行了MRI和磁共振血管造影的急性缺血性中风患者。采用T2*加权梯度回波序列来定义CMBs。比较有和没有CMBs的患者的基线特征、中风亚型和白质病变严重程度。
200名患者纳入研究。患者的平均年龄为61岁。美国国立卫生研究院卒中量表平均分为8分。CMBs的患病率为20%（39/200例患者）。高血压（优势比[OR]3.05，95%置信区间[CI]1.07 - 8.68，P = 0.037）和中度至重度白质病变（Fazekas 2 - 3级，OR 7.61，95% CI 3.06 - 18.95，P < 0.001）与CMBs的存在相关。
在20%的缺血性中风患者中发现了CMBs，这低于日本研究报告的患病率，但与一项中国研究相当。CMBs与高血压和白质病变的严重程度相关。
