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双歧杆菌:一种新出现的、临床上具有重要意义的、耐甲硝唑的混合性化脓性感染厌氧菌。

Bifidobacterium: An Emerging Clinically Significant Metronidazole-resistant Anaerobe of Mixed Pyogenic Infections.

作者信息

Butta Hena, Sardana Raman, Vaishya Raju, Singh Kailash N, Mendiratta Leena

机构信息

Microbiology, Indraprastha Apollo Hospitals.

Orthopaedics, Indraprastha Apollo Hospitals.

出版信息

Cureus. 2017 Apr 4;9(4):e1134. doi: 10.7759/cureus.1134.

DOI:10.7759/cureus.1134
PMID:28480152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5418030/
Abstract

sp. are anaerobic, Gram-positive, short, irregular rods with rudimentary branching. These organisms are reported to be associated with health benefits and their significance as a pathogen is not much reported. We are reporting two cases of mixed pyogenic infections due to sp. In the first patient, the infection mimicked tubercular bone infection. The second patient was a case of hydronephrosis with double J (DJ) stent blockage. In both cases,  sp. was isolated in combination with from the evacuated pus samples. The factors which contributed significantly for detecting sp. were gram stain examination, use of rapid and automatic anaerobic cultivation system (Anoxomat, MART Microbiology B.V., The Netherlands), and quick identification by MALDI-TOF (Matrix-Assisted Laser Desorption-Time-of-Flight) Mass Spectrometry (Biomerieux, France). Both strains were found to be resistant to metronidazole and both patients showed a good clinical response to treatment with beta-lactam antibiotics. So, we highlight the importance of seeking species in all clinical pyogenic samples.

摘要

某菌属为厌氧菌,革兰氏阳性,呈短而不规则的杆状,有基本分支。据报道,这些微生物具有健康益处,关于其作为病原体的重要性报道不多。我们报告了两例由某菌属引起的混合性化脓性感染病例。在第一例患者中,感染类似结核性骨感染。第二例患者是双J(DJ)支架堵塞导致的肾积水病例。在这两例病例中,均从引流的脓液样本中分离出某菌属与其他菌。对检测某菌属有显著贡献的因素包括革兰氏染色检查、使用快速自动厌氧培养系统(Anoxomat,荷兰MART微生物学有限公司)以及通过基质辅助激光解吸飞行时间(MALDI-TOF)质谱法(法国生物梅里埃公司)进行快速鉴定。两株菌株均对甲硝唑耐药,两名患者对β-内酰胺类抗生素治疗均显示出良好的临床反应。因此,我们强调在所有临床化脓性样本中寻找该菌属的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6604/5418030/2c4aec5cf07d/cureus-0009-00000001134-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6604/5418030/ecabf3d3b1db/cureus-0009-00000001134-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6604/5418030/2c4aec5cf07d/cureus-0009-00000001134-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6604/5418030/ecabf3d3b1db/cureus-0009-00000001134-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6604/5418030/2c4aec5cf07d/cureus-0009-00000001134-i02.jpg

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