Nakazawa T, Kaneko K, Takahashi H, Inoue S
Department of Pediatrics, Juntendo University School of Medicine, Juntendo Urayasu Hospital, Chiba, Japan.
Brain Dev. 1996 Mar-Apr;18(2):160-2. doi: 10.1016/0387-7604(95)00149-2.
We are reporting a male neonate with meningitis caused by Bifidobacterium breve. This is only the second case reported so far to our knowledge. The patient's clinical course was excellent and inflammatory indications, such as serum C-reactive protein, were weak. Although the antibiotics used for the patient were effective against this bacterium both in vitro and in vivo, two relapses occurred which might have been caused by an incomplete remission due to the low permeability of antibiotics through the blood-brain barrier under the very mild inflammation of the meninges, and also by the discrepancy between minimum bactericidal concentrations (MBC) and minimum inhibitory concentrations (MIC). Anaerobic meningitis is very rare, but it may exist in more than the reported cases. Anaerobic culture should be performed for patients with culture-negative purulent meningitis.
我们报告了一例由短双歧杆菌引起脑膜炎的男性新生儿。据我们所知，这是迄今为止报告的第二例病例。患者的临床病程良好，血清C反应蛋白等炎症指标较弱。尽管用于该患者的抗生素在体外和体内对这种细菌均有效，但仍发生了两次复发，这可能是由于在非常轻微的脑膜炎症下抗生素透过血脑屏障的通透性低导致缓解不完全，以及最低杀菌浓度（MBC）与最低抑菌浓度（MIC）之间的差异所致。厌氧性脑膜炎非常罕见，但实际存在的病例可能比报告的更多。对于培养阴性的化脓性脑膜炎患者应进行厌氧菌培养。
