Hou Xue-Qin, Wang Lei, Wang Fu-Gang, Zhao Xiao-Min, Zhang Han-Ting
Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China.
Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology, Blanchette Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
Genes (Basel). 2017 May 6;8(5):135. doi: 10.3390/genes8050135.
RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.
RNA干扰（RNAi），包括微小RNA，是通过靶基因介导干细胞分化和迁移的重要参与者。它被用作治疗中枢神经系统（CNS）疾病的一种潜在基因治疗策略。由于干细胞能够将RNAi传递给其他细胞，因此被视为RNAi的载体。在本综述中，我们讨论了RNAi途径在控制干细胞神经元分化和迁移方面的研究最新进展。我们还强调了RNAi与干细胞联合应用于治疗中枢神经系统疾病的情况。
