静脉注射头孢曲松治疗梅毒性葡萄膜炎。

Intravenous Ceftriaxone for Syphilitic Uveitis.

机构信息

a Uveitis Unit, Hospital São Geraldo / Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

b Faculdade de Medicina , Universidade Federal do Espírito Santo , Vitória , Brazil.

出版信息

Ocul Immunol Inflamm. 2018;26(7):1059-1065. doi: 10.1080/09273948.2017.1311926. Epub 2017 May 8.

DOI:10.1080/09273948.2017.1311926

PMID:28481679

Abstract

PURPOSE

Report of clinical/multimodal imaging outcomes of patients with syphilitic uveitis alternatively treated with intravenous(IV) ceftriaxone, due to unavailability of penicillin G.

METHODS

Chart review of all cases of syphilitic uveitis presenting to Hospital São Geraldo/HC-UFMG and treated with intravenous ceftriaxone, between January and August 2014. Clinical, serological and ophthalmological data were collected.

RESULTS

Twelve consecutive patients with syphilitic uveitis receiving IV ceftriaxone were identified. All 24 eyes had active intraocular inflammation on clinical examination. All patients received IV ceftriaxone (2-4 g daily) for 14-21 days, supplemented with oral corticosteroid as needed in 9 patients (75%), after documented clinical response. Improvement in intraocular inflammation was seen in all 24 eyes, with median best-corrected visual acuity (BCVA) increasing from 20/50 to 20/20, after a mean follow-up of 5.3 months.

CONCLUSION

IV ceftriaxone may be an effective alternative for treatment of syphilitic uveitis, in the setting of unavailability of penicillin G.

摘要

目的

报告因无法获得青霉素 G 而改用静脉注射（IV）头孢曲松治疗的梅毒性葡萄膜炎患者的临床/多模态影像学结果。

方法

对 2014 年 1 月至 8 月期间在圣加多医院/HC-UFMG 就诊并接受静脉注射头孢曲松治疗的所有梅毒性葡萄膜炎患者进行病例回顾。收集了临床、血清学和眼科数据。

结果

确定了 12 例连续接受 IV 头孢曲松治疗的梅毒性葡萄膜炎患者。所有 24 只眼在临床检查中均存在活动性眼内炎症。所有患者均接受 IV 头孢曲松（2-4 g/天）治疗 14-21 天，9 例患者（75%）在有临床反应记录后，根据需要口服皮质类固醇。24 只眼中的所有眼内炎症均有改善，平均随访 5.3 个月后，最佳矫正视力（BCVA）中位数从 20/50 增加到 20/20。