Khairy May Ahmed, Abuelhamed Walaa Alsharany, Ahmed Radwa Sayed, El Fouly Hedayet El Sayed, Elhawary Ismail Mohamed
a Pediatrics, New Children Hospital, (Abu El Rish) , Children Hospital, Cairo University Hospitals, Cairo University , Cairo , Egypt.
b Faculty of Medicine, Audiology , Cairo University Kasr Alainy , Cairo , Egypt.
J Matern Fetal Neonatal Med. 2018 Jul;31(13):1756-1761. doi: 10.1080/14767058.2017.1326902. Epub 2017 May 22.
The aim of this work is to identify the most significant risk factors for hearing impairment in high risk neonates hospitalized at our Neonatal Intensive Care Unit (NICU) and to assess the sensitivity of hearing screening tests.
This study involved 260 neonates admitted to a tertiary NICU; they were classified into two groups; 150 preterm and 110 full terms with risk factors for hearing loss. The hearing screening tests performed were transient evoked otoacoustic emissions (TEOAEs) and the automated auditory brainstem response (AABR).
Forty-eight preterm neonates (32%) and 30 full term neonates (27.3%) had pathological AABR. In preterm group, mechanical ventilation more than five days, sepsis, usage of aminoglycosides, loop diuretics, vancomycin alone or in combination with aminoglycosides and prolonged duration of admission were considered risk factors of hearing affection whereas in full term group mechanical ventilation more than five days was the risk factor of hearing affection (p<.05).
The prevalence of hearing loss is highest among high risk neonates and TEOAE and AABR were found to be reliable screening tools. Use of ototoxic drugs and mechanical ventilation for more than five days were significant risk factors for hearing loss in our study population.
本研究旨在确定入住我院新生儿重症监护病房(NICU)的高危新生儿听力损伤的最显著危险因素,并评估听力筛查测试的敏感性。
本研究纳入了260名入住三级NICU的新生儿;他们被分为两组;150名早产儿和110名有听力损失危险因素的足月儿。所进行的听力筛查测试为瞬态诱发耳声发射(TEOAEs)和自动听性脑干反应(AABR)。
48名早产儿(32%)和30名足月儿(27.3%)的AABR结果异常。在早产儿组中,机械通气超过5天、败血症、使用氨基糖苷类药物、袢利尿剂、单独使用万古霉素或与氨基糖苷类药物联合使用以及住院时间延长被认为是听力受损的危险因素,而在足月儿组中,机械通气超过5天是听力受损的危险因素(p<0.05)。
高危新生儿中听力损失的患病率最高,并发现TEOAE和AABR是可靠的筛查工具。在我们的研究人群中,使用耳毒性药物和机械通气超过5天是听力损失的重要危险因素。