DeZern Amy E, Binder Gary, Rizvi Syed, Corvino Frank A, Arikian Steven R, Surinach Andy, Lee Jianyi, Smith B Douglas
a Sidney Kimmel Comprehensive Cancer Center , Johns Hopkins University , Baltimore , MD , USA.
b Celgene Corporation , Summit , NJ , USA.
Leuk Lymphoma. 2017 Nov;58(11):2649-2656. doi: 10.1080/10428194.2017.1312372. Epub 2017 May 9.
Transfusion dependence (TD) among myelodysplastic syndromes (MDS) patients negatively impacts survival and health-related quality of life. We evaluated cost patterns of MDS care during TD and transfusion independence (TI). MDS patients were identified from a US claims database (2008-2013). TD was defined as ≥2 consecutive 8-week periods with ≥1 claim during each, and no interim 56-day period without transfusion; TI as 8 subsequent transfusion-free weeks; and transfusion frequency as the mean interval between transfusions during the TD period. 13,741 patients were included; 19% were TD and 70% had a mean interval between transfusions of ≤28 days. During a 2-year period, TD patients incurred a mean total cost of $17,815/patient-month; 53% higher for those with ≤28 days ($19,498) vs. >28 days ($12,717) between transfusions. Among patients who achieved TI, mean total cost was $7874/patient-month. For TD-MDS patients, cost increases are proportional to transfusion frequency and achieving TI yields economic benefits.
骨髓增生异常综合征（MDS）患者的输血依赖（TD）对生存及健康相关生活质量产生负面影响。我们评估了TD期及非输血依赖期（TI）MDS治疗的费用模式。从美国索赔数据库（2008 - 2013年）中识别出MDS患者。TD定义为连续≥2个8周期间，每个期间至少有1次索赔，且中间无56天无输血期；TI为随后连续8周无输血；输血频率为TD期输血的平均间隔时间。共纳入13741例患者；19%为TD患者，70%输血平均间隔时间≤28天。在2年期间，TD患者平均每月总费用为17815美元/患者；输血间隔≤28天者（19498美元）比>28天者（12717美元）高出53%。在实现TI的患者中，平均每月总费用为7874美元/患者。对于TD - MDS患者，费用增加与输血频率成正比，实现TI可带来经济效益。
