Wang Tao, Su Beibei, Han Dawei, Tong Anli, Li Jian, Liu Yuehua, Jin Hongzhong, Fang Kai
Department of Dermatology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
1 Department of Dermatology, PUMC Hospital,CAMS and PUMC,Beijing 100730,China; 2 Department of Dermatology,Xinxiang Central Hospital,Xinxiang,Henan 453000,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017 Apr 20;39(2):206-210. doi: 10.3881/j.issn.1000-503X.2017.02.007.
Objective To investigate the features of Langerhans cell histiocytosis (LCH). Skin lesions,systemic involvement,imaging characteristics,laboratory tests,immunophenotying,treatment response,and survival of 122 LCH patients treated at our center from February 1983 to August 2013 were retrospectively analyzed. Results LCH was associated with diverse skin lesions. Lung was the most involved organ,followed by bone,skin,lymph nodes,liver,spleen,oral cavity,and thyroid. Multisystem LCH was more common than single-system LCH. Single-system LCH was mostly treated by surgery,whereas multisystem LCH by combined chemotherapy. Conclusion LCH has diverse clinical manifestations,with lungs being the most often involved organ. Surgery or chemotherapy is the mainstream treatment.
目的 探讨朗格汉斯细胞组织细胞增多症（LCH）的特征。回顾性分析1983年2月至2013年8月在本中心接受治疗的122例LCH患者的皮肤病变、全身受累情况、影像学特征、实验室检查、免疫表型、治疗反应及生存情况。结果 LCH与多种皮肤病变相关。肺部是最常受累的器官，其次是骨骼、皮肤、淋巴结、肝脏、脾脏、口腔和甲状腺。多系统LCH比单系统LCH更常见。单系统LCH大多采用手术治疗，而多系统LCH采用联合化疗。结论 LCH有多种临床表现，肺部是最常受累的器官。手术或化疗是主要治疗方法。
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