Gui Juan, Wang Rui-Hao
Department of Obstetrics, Gynecology, Renmin Hospital of Wuhan University, Wuhan, China; Assisted Reproduction and Embryogenesis Clinical Research Center of Hubei Province, Wuhan, China.
Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany.
Reprod Biomed Online. 2017 Jul;35(1):113-120. doi: 10.1016/j.rbmo.2017.03.018. Epub 2017 Apr 7.
Recent studies reveal that polycystic ovary syndrome (PCOS) might be associated with cardiovascular autonomic dysfunction, but with inconsistent results. The aim of this meta-analysis was to study whether women with PCOS have cardiovascular autonomic dysfunction. PubMed, Web of Science, Cochrane Library and SCOPUS were searched for studies comparing cardiovascular function between women with PCOS and controls. A random-effects model was used to evaluate cardiac autonomic modulation and muscle sympathetic nerve activity (MSNA) between women with PCOS and controls. Eight studies were included, including 243 PCOS and 211 controls. Overall, women with PCOS had significantly lower standard deviation of normal-to-normal RR intervals (SDNN) and percentage of the number of interval differences of successive normal-to-normal RR intervals greater than 50 ms among the total number of RR intervals (pNN50), higher MSNA frequency and higher MSNA incidence than controls. Therefore, this meta-analysis provides evidence that women with PCOS might show cardiovascular autonomic dysfunction, with reduced total and parasympathetic cardiac modulation, and increased sympathetic activity.
近期研究表明，多囊卵巢综合征（PCOS）可能与心血管自主神经功能障碍有关，但结果并不一致。本荟萃分析的目的是研究PCOS女性是否存在心血管自主神经功能障碍。检索了PubMed、科学网、Cochrane图书馆和SCOPUS，以查找比较PCOS女性与对照组心血管功能的研究。采用随机效应模型评估PCOS女性与对照组之间的心脏自主神经调节和肌肉交感神经活动（MSNA）。纳入了八项研究，包括243例PCOS患者和211例对照。总体而言，PCOS女性的正常RR间期标准差（SDNN）和RR间期总数中连续正常RR间期差异大于50毫秒的间期差异数百分比（pNN50）显著低于对照组，MSNA频率和MSNA发生率高于对照组。因此，本荟萃分析提供了证据，表明PCOS女性可能表现出心血管自主神经功能障碍，总心脏调节和副交感神经心脏调节降低，交感神经活动增加。
