LRRK2-G2019S型帕金森病中的肠道α-突触核蛋白病理学 - Suppr

Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.

作者信息

Rouaud Tiphaine, Clairembault Thomas, Coron Emmanuel, Neunlist Michel, Anheim Mathieu, Derkinderen Pascal

机构信息

Inserm, CIC-04, Nantes F-44093, France; Inserm, U1235, Nantes F-44035, France; University Nantes, Nantes F-44035, France; CHU Nantes, Department of Neurology, Nantes F-44093, France.

Inserm, U1235, Nantes F-44035, France; University Nantes, Nantes F-44035, France.

出版信息

Parkinsonism Relat Disord. 2017 Jul;40:83-84. doi: 10.1016/j.parkreldis.2017.05.001. Epub 2017 May 3.

DOI:10.1016/j.parkreldis.2017.05.001

PMID:28483388

Abstract

摘要

相似文献

Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.

Parkinsonism Relat Disord. 2017 Jul;40:83-84. doi: 10.1016/j.parkreldis.2017.05.001. Epub 2017 May 3.

LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease.

Curr Med Sci. 2018 Dec;38(6):1012-1017. doi: 10.1007/s11596-018-1977-z. Epub 2018 Dec 7.

Lack of central and peripheral nervous system synuclein pathology in R1441G -associated Parkinson's disease.

J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):832-833. doi: 10.1136/jnnp-2018-318473. Epub 2018 Jul 27.

LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation.

Neurobiol Dis. 2020 Oct;144:105049. doi: 10.1016/j.nbd.2020.105049. Epub 2020 Aug 13.

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

Neurobiol Dis. 2015 May;77:49-61. doi: 10.1016/j.nbd.2015.02.019. Epub 2015 Feb 28.

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Acta Neuropathol Commun. 2018 May 31;6(1):45. doi: 10.1186/s40478-018-0550-0.

Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.

Brain. 2018 Feb 1;141(2):486-495. doi: 10.1093/brain/awx344.

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.

Neurobiol Dis. 2013 Oct;58:183-90. doi: 10.1016/j.nbd.2013.05.017. Epub 2013 Jun 5.

Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.

Adv Neurobiol. 2017;14:209-226. doi: 10.1007/978-3-319-49969-7_11.

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.

J Neuroinflammation. 2016 Nov 18;13(1):295. doi: 10.1186/s12974-016-0761-x.

引用本文的文献

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.

Front Neurosci. 2020 Aug 18;14:865. doi: 10.3389/fnins.2020.00865. eCollection 2020.

Altered Gut Microbiome and Intestinal Pathology in Parkinson's Disease.

J Mov Disord. 2019 May;12(2):67-83. doi: 10.14802/jmd.18067. Epub 2019 May 30.

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Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.

作者信息

Rouaud Tiphaine, Clairembault Thomas, Coron Emmanuel, Neunlist Michel, Anheim Mathieu, Derkinderen Pascal

机构信息

Inserm, CIC-04, Nantes F-44093, France; Inserm, U1235, Nantes F-44035, France; University Nantes, Nantes F-44035, France; CHU Nantes, Department of Neurology, Nantes F-44093, France.

Inserm, U1235, Nantes F-44035, France; University Nantes, Nantes F-44035, France.

出版信息

Parkinsonism Relat Disord. 2017 Jul;40:83-84. doi: 10.1016/j.parkreldis.2017.05.001. Epub 2017 May 3.

DOI:10.1016/j.parkreldis.2017.05.001

PMID:28483388

Abstract

摘要

相似文献

Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.

Parkinsonism Relat Disord. 2017 Jul;40:83-84. doi: 10.1016/j.parkreldis.2017.05.001. Epub 2017 May 3.

LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease.

Curr Med Sci. 2018 Dec;38(6):1012-1017. doi: 10.1007/s11596-018-1977-z. Epub 2018 Dec 7.

Lack of central and peripheral nervous system synuclein pathology in R1441G -associated Parkinson's disease.

J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):832-833. doi: 10.1136/jnnp-2018-318473. Epub 2018 Jul 27.

LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation.

Neurobiol Dis. 2020 Oct;144:105049. doi: 10.1016/j.nbd.2020.105049. Epub 2020 Aug 13.

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

Neurobiol Dis. 2015 May;77:49-61. doi: 10.1016/j.nbd.2015.02.019. Epub 2015 Feb 28.

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Acta Neuropathol Commun. 2018 May 31;6(1):45. doi: 10.1186/s40478-018-0550-0.

Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.

Brain. 2018 Feb 1;141(2):486-495. doi: 10.1093/brain/awx344.

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.

Neurobiol Dis. 2013 Oct;58:183-90. doi: 10.1016/j.nbd.2013.05.017. Epub 2013 Jun 5.

Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.

Adv Neurobiol. 2017;14:209-226. doi: 10.1007/978-3-319-49969-7_11.

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.

J Neuroinflammation. 2016 Nov 18;13(1):295. doi: 10.1186/s12974-016-0761-x.

引用本文的文献

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.

Front Neurosci. 2020 Aug 18;14:865. doi: 10.3389/fnins.2020.00865. eCollection 2020.

Altered Gut Microbiome and Intestinal Pathology in Parkinson's Disease.

J Mov Disord. 2019 May;12(2):67-83. doi: 10.14802/jmd.18067. Epub 2019 May 30.

Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.

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Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.

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