Steiner G C, Graham S, Lewis M M
Department of Pathology, Hospital for Joint Diseases-Orthopedic Institute, New York, New York 10003.
Ultrastruct Pathol. 1988 Sep-Oct;12(5):505-12. doi: 10.3109/01913128809032235.
A malignant round cell tumor primary in bone is reported in a young girl, showing histologically rosette formation and pseudoalveolar spaces. Vimentin, NSE, and S-100 were positive. Electron microscopy demonstrated abundant glycogen and neural features such as cell processes, microtubules, and occasional dense-core granules. Whether this neuroectodermal tumor represents a separate entity or is a variant of Ewing's sarcoma should wait for further experience, in the light of recent evidence suggesting that Ewing's sarcoma arises from primitive multipotential cells.
据报道，一名年轻女孩患有原发性骨恶性圆形细胞瘤，组织学表现为菊形团形成和假腺泡间隙。波形蛋白、神经元特异性烯醇化酶和S-100呈阳性。电子显微镜显示有丰富的糖原以及神经特征，如细胞突起、微管和偶尔的致密核心颗粒。鉴于最近有证据表明尤因肉瘤起源于原始多能细胞，这种神经外胚层肿瘤是代表一个独立的实体还是尤因肉瘤的一种变体，还有待进一步研究。
