Parravano Mariacristina, De Geronimo Daniele, Scarinci Fabio, Querques Lea, Virgili Gianni, Simonett Joseph Michael, Varano Monica, Bandello Francesco, Querques Giuseppe
Fondazione G.B. Bietti-IRCCS, Rome, Italy.
Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.
Am J Ophthalmol. 2017 Jul;179:90-96. doi: 10.1016/j.ajo.2017.04.021. Epub 2017 May 5.
To correlate the appearance of microaneurysms (MAs) on structural spectral-domain optical coherence tomography (SDOCT) with their detection on OCT angiography (OCTA) in patients with nonproliferative diabetic retinopathy (NPDR).
Interinstrument reliability study.
Sixteen patients with NPDR without macular edema underwent SDOCT and OCTA. To compare MAs seen on OCTA with those on SDOCT, we superimposed the OCTA superficial capillary plexus (SCP) vascular landmarks onto those of the near infrared. Two observers masked to patient groupings evaluated reflectivity of MAs on SDOCT scans, graded as hyporeflective, moderate, or hyperreflective, and their visualization at the level of SCP and deep capillary plexus (DCP) on OCTA.
Among 145 MAs imaged with SDOCT, 47 (32.4%) appeared as hyperreflective, 71 (49.0%) as moderately reflective, and 27 (18.6%) as hyporeflective. After excluding 3 eyes (10 MAs) because of poor-quality OCTA scans, 135 MAs were evaluated on OCTA; 76 (56.3%) were visible only in the DCP, 9 (6.7%) only in the SCP, 29 (21.5%) were visible in both SCP and DCP; and 21 (15.6%) were not visible on OCTA. Compared with MAs with hyperreflectivity or moderate reflectivity, MAs with hyporeflectivity on structural SDOCT were significantly less likely to be detected on OCTA (odds ratio [OR]: 4.6; 95% confidence interval [CI]: 1.5-14.0, P = .008; and OR: 4.2, 95% CI: 1.2-14.2, P = .022, respectively).
MAs that appear hyporeflective on structural SDOCT have a lower detection rate on OCTA. The results of this study may help further understand the different blood flow dynamics pattern in MAs.
在非增殖性糖尿病视网膜病变（NPDR）患者中，将结构谱域光学相干断层扫描（SDOCT）上微动脉瘤（MA）的表现与其在光学相干断层扫描血管造影（OCTA）上的检测结果进行关联。
仪器间可靠性研究。
16例无黄斑水肿的NPDR患者接受了SDOCT和OCTA检查。为了比较OCTA上所见的MA与SDOCT上的MA，我们将OCTA浅表毛细血管丛（SCP）血管标记叠加到近红外的血管标记上。两名对患者分组情况不知情的观察者评估了SDOCT扫描上MA的反射率，分为低反射、中等反射或高反射，并评估了它们在OCTA上SCP和深层毛细血管丛（DCP）层面的可视性。
在145个用SDOCT成像的MA中，47个（32.4%）表现为高反射，71个（49.0%）表现为中等反射，27个（18.6%）表现为低反射。由于OCTA扫描质量差而排除3只眼（10个MA）后，在OCTA上评估了135个MA；76个（56.3%）仅在DCP中可见，9个（6.7%）仅在SCP中可见，29个（21.5%）在SCP和DCP中均可见；21个（15.6%）在OCTA上不可见。与高反射或中等反射的MA相比，结构SDOCT上低反射的MA在OCTA上被检测到的可能性显著降低（优势比[OR]：4.6；95%置信区间[CI]：1.5 - 14.0，P = .008；以及OR：4.2，95% CI：1.2 - 14.2，P = .022）。
在结构SDOCT上表现为低反射的MA在OCTA上的检测率较低。本研究结果可能有助于进一步了解MA中不同的血流动力学模式。
