Kato Akihisa
Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo.
Uirusu. 2016;66(1):83-90. doi: 10.2222/jsv.66.83.
Herpes simplex virus type-1 (HSV-1) causes a range of human diseases, from mild uncomplicated mucocutaneous infection to life-threatening ones. The Us3 gene of HSV-1 encodes a serine/threonine protein kinase that is highly conserved among alphaherpesviruses. Accumulating evidence suggests that Us3 is a critical regulator of HSV-1 infection; however, the molecular mechanism by which Us3 regulates HSV-1 pathogenicity remains to be elucidated. This article presents a brief summary of the present knowledge on the roles of HSV-1 Us3, with a special focus on its relevancy in vivo.
1型单纯疱疹病毒（HSV-1）可引发一系列人类疾病，从轻度的无并发症黏膜皮肤感染到危及生命的疾病。HSV-1的Us3基因编码一种丝氨酸/苏氨酸蛋白激酶，该激酶在α疱疹病毒中高度保守。越来越多的证据表明，Us3是HSV-1感染的关键调节因子；然而，Us3调节HSV-1致病性的分子机制仍有待阐明。本文简要总结了目前关于HSV-1 Us3作用的知识，特别关注其在体内的相关性。
