Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.
Sci Rep. 2017 May 8;7(1):1583. doi: 10.1038/s41598-017-01719-y.
To define the features of glycemic variations in drug naïve type 2 diabetic (T2D) patients with different HbA values using continuous glucose monitoring (CGM), a total of 195 drug naïve T2D patients were admitted. The subjects were divided into the following groups: lower HbA values (≤8%), moderate HbA values (>8% and ≤10%), and higher HbA values (>10%). The patients underwent oral glucose tolerance tests and were then subjected to 3-day CGM. The primary endpoint was the differences in the 24-hr mean amplitude of glycemic excursions (MAGE) in patients with different HbA values. Patients with higher HbA values had larger MAGEs than those in the moderate and lower groups (7.44 ± 3.00 vs. 6.30 ± 2.38, P < 0.05, 7.44 ± 3.00 vs. 5.20 ± 2.35, P < 0.01, respectively). The 24-hr mean glucose concentrations increased incrementally in the patients with lower, moderate and higher HbA values. Moreover, the patients with higher HbA values exhibited higher peak glucose concentrations and prolongation in the time to peak glucose. Patients with higher HbA values had larger MAGE compared with those with lower and moderate HbA values. Our data indicated patients with higher HbA values should receive special therapy aimed at reducing the larger glycemic variations.
为了使用连续血糖监测（CGM）定义不同糖化血红蛋白（HbA）值的初诊 2 型糖尿病（T2D）患者血糖变化的特征，共纳入 195 例初诊 T2D 患者。将受试者分为以下几组：HbA 值较低（≤8%）、HbA 值中等（>8%且≤10%）和 HbA 值较高（>10%）。患者接受口服葡萄糖耐量试验，然后进行 3 天 CGM。主要终点是不同 HbA 值患者的 24 小时平均血糖波动幅度（MAGE）的差异。HbA 值较高的患者的 MAGE 高于中值和低值组（7.44±3.00 比 6.30±2.38，P<0.05；7.44±3.00 比 5.20±2.35，P<0.01）。HbA 值较低、中等和较高的患者 24 小时平均血糖浓度逐渐升高。此外，HbA 值较高的患者表现出更高的峰值血糖浓度和峰值血糖时间延长。HbA 值较高的患者的 MAGE 高于 HbA 值较低和中等的患者。我们的数据表明，HbA 值较高的患者应接受旨在降低较大血糖波动的特殊治疗。
